THE COGNIGENICS APPROACH
Genetic therapeutics represent a transformative advancement in biopharmacology, enabling the precise manipulation of DNA (permanent) or RNA (temporary) sequences. This new class of medicines can insert, delete, or modify specific genetic sequences, allowing for more effective mental health treatments.
Unlike traditional pharma drugs, which are taken systemically and can cause undesirable side effects, genetic medicines offer the promise of targeting only those neuronal receptors or neuronal circuits in the brain that are responsible for the disorder, vastly reducing possible side effects. In addition, unlike genetic-based vaccines, these therapeutic medicines do not introduce foreign proteins into the body, so they do not provoke immune responses, and nor do the RNA treatments affect DNA.
LIMITATIONS OF CURRENT TREATMENTS IN ANXIETY AND DEPRESSION
- Outdated Pharmacological Options
Current anxiolytic and memory drugs were developed in the 1980s and 1990s. This presents a significant opportunity for innovative breakthroughs in treatment approaches.
- Limited Effectiveness and Adverse Side Effects of SSRIs
Common SSRIs like Prozac, Celexa, and Zoloft offer limited efficacy and are associated with a range of serious side effects. More effective and safer treatment alternatives are needed.
- Inadequate Response Rates to SSRIs
Research indicates that 30% to 50% of patients suffering from anxiety disorders do not find adequate relief with SSRIs.
- High Relapse Rates
Individuals with anxiety disorders often face relapse rates between 50% to 80% over several years, even with ongoing treatment.
- Adverse Effects of Long-Term Medication Use
Prolonged use of benzodiazepines can lead to drug dependence. Side effects of SSRIs, such as sexual dysfunction, chronic nausea, impaired digestion, dry mouth, weight gain, sleep disturbances, and in extreme cases, increased suicidal ideation, further complicate treatment adherence and effectiveness.
These challenges point to a pressing need for novel, more effective, and safer therapeutic interventions in the realm of mental health.